Resistance development to Tiamutin by M. gallisepticum is very slow [?] in comparison with tylosin as Tiamutin requires a multiple step mutation. (See chart below).
Another study [?] compared the rate of resistance development of Tiamutin with tylosin, oxytetracycline and enrofloxacin and again showed Tiamutin 3-5 times slower to develop resistance than the other antimicrobials (see table below).
| Resistance |
Drews (1975) |
| Development of resistance against M. gallisepticum |
 |
| Resistance |
Stipkovits, L. and others (1992) |
| Resistance development |
| Antibiotic |
Number of passages |
MIC (µg/ml) |
| Tiamutin® (tiamulin) |
64 |
32 |
| Oxytetracycline |
21 |
32 |
| Enrofloxacin |
21 |
32 |
| Tylosin |
13 |
2048 |
|
| 
