Denagard is incompatible at prevention and treatment levels with the anticoccidials salinomycin, monensin and narasin.
Care must be taken to avoid the use of these products in feed when using Denagard otherwise signs of interaction such as growth depression, water intake depression, paralysis and even death will occur.
The safety margins of the incompatible ionophores are fairly narrow. Salinomycin and narasin are highly toxic to turkeys on their own. If their metabolism and excretion is inhibited this leads to a build up of the products and this will cause an overdosage effect.
Denagard, as well as other substances such as chloramphenicol, erythromycin and some sulpha drugs, interferes with their metabolism and will cause variable degrees of interaction.
The interaction is dose related in that low doses of Denagard up to 50 ppm in feed do not cause any signs to occur. Therefore low level cross-contamination at the mill with Denagard (up to 50 ppm) is not considered to be a major hazard.