Broad spectrum

Tiamutin has also shown a synergistic activity with the tetracyclines.[?] When combined with chlortetracycline there was a 5 times increase in activity against M. gallisepticum and 4-8 times increase against Pasteurellae.
 

Similar results have been shown with Tiamutin and
doxycycline.[?]
 

Both Tiamutin and the tetracyclines are bacteriostatic antibiotics both acting on the ribosome, the sites where proteins are produced in the organism. It is thought their similar mode of action enhances their antimicrobial activity.

Six week old birds, with a naturally occurring M. gallisepticum infection in groups of 30 were inoculated subcutaneously
with E. coli. They were medicated for 3 days in the drinking water and monitored for 2 weeks.
 

The combination of Tiamutin and oxytetracycline (OTC) reduced the losses from Coli-septicaemia better than Tiamutin alone and doxycycline on its own. The higher level was marginally better than the lower level.