The term Porcine Respiratory Disease Complex (PRDC) is used to describe new and severe problems observed in finishing units where M. hyo and PRRS virus play a significant role.
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Mycoplasmas  colonise the respiratory tract... |
damage cilia and cells and... |
allow P. multocida  and other secondary pathogens to invade |
US research has demonstrated that M. hyo enhances the severity and duration of PRRS virus induced pneumonia. [?]
Swine influenza virus, porcine circovirus type 2 (PCV-2), Pasteurella multocida, Actinobacillus pleuropneumoniae, Streptococcus suis and Haemophilus parasuis also often contribute to the syndrome.
Denagard has been shown to be one of the most potent antibiotics against M. hyo. However, in PRDC the wide range of bacteria/mycoplasma involved are best controlled in-feed by the synergistic broad spectrum combination of Denagard and chlortetracycline or doxycycline [?] premixes. (See here)
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