Tiamulin is a highly active antimicrobial in vitro against M. hyopneumoniae. [?]
This has been confirmed, amongst others, in reports from Hungary [?], [?] Korea [?], Canada [?] and Thailand [?]. (See tables below)
| HUNGARY |
Stipkovits, L. and others (1992) |
| Average MIC values (µg/ml) of eight isolates of M. hyopneumoniae to various antimicrobials |
 |
| KOREA |
Koh, H.B. (1994) |
| MICs (µg/ml) of seven field isolates of M. hyopneumoniae to seven antimicrobials |
| Antimicrobial |
MIC (µg/ml) |
| 0.1 |
0.2 |
0.4 |
0.8 |
1.6 |
3.2 |
6.3 |
12.5 |
Tiamutin®
(tiamulin) |
- |
- |
5 |
2 |
- |
- |
- |
- |
|
|
|
(71.4%) |
(28.6%) |
|
|
|
|
| Danofloxacin |
- |
- |
- |
1 |
6 |
- |
- |
- |
| |
|
|
|
(14.3%) |
(85.7%) |
|
|
|
| Enrofloxacin |
- |
- |
- |
4 |
3 |
- |
- |
- |
| |
|
|
|
(57.1%) |
(42.9%) |
|
|
|
| Oxytetracycline |
- |
- |
- |
5 |
- |
2 |
- |
- |
| |
|
|
|
(71.4%) |
|
(28.6%) |
|
|
| Tylosin |
- |
- |
- |
- |
1 |
6 |
- |
- |
| |
|
|
|
|
(14.3%) |
(85.7%) |
|
|
| Norflaxin |
- |
- |
- |
- |
- |
7 |
- |
- |
| |
|
|
|
|
|
(100%) |
|
|
| Lincomycin/ |
- |
- |
- |
- |
- |
6 |
1 |
- |
| Spectinomycin |
|
|
|
|
|
(85.7%) |
(14.3%) |
|
|
| CANADA |
Desrosiers, R. (2001) |
| Average MICs for M. hyo of four antimicrobial agents used to control M. hyo in commercial pig units |
| Ref. Author/Year |
No of strains
M.hyo |
MIC (µg/ml) |
| Lincomycin |
Oxytetracycline |
Tylosin |
Tiamutin® (tiamulin) |
Yamamoto 1986
(Japan) |
55 |
0.12 |
0.74 |
0.06 |
0.03 |
Inamoto 1994
(Japan) |
25 |
0.06 |
1.2 |
0.03 |
0.02 |
Hannan 1997
(UK) |
20 |
ND* |
1 |
0.25 |
0.05 |
|
| THAILAND |
Thongkamkoon, P. and others (2002) |
| MICs (µg/ml) for 28 strains of M. hyo determined by microtiter plate test |
| Antimicrobial |
MIC range
|
MIC50
|
MIC90
|
| Oxytetracycline |
<0.024 - 0.78
|
0.195
|
0.39
|
| Lincomycin |
<0.006 - 0.39
|
0.048
|
0.097
|
| Spectinomycin |
<0.024 - 100
|
0.39
|
1.56
|
| Tilmicosin |
<0.024 - 3.125
|
0.39
|
1.56
|
| Tiamutin® (tiamulin) |
<0.006 - 0.097
|
0.006
|
0.048
|
|
The application of Tiamutin medication (either by injection, food or water), in conjunction with management changes, such as isolation, use of emptied and disinfected pens and segregated rearing of piglets, has been shown to be a key component of successful strategies to eliminate
M. hyopneumoniae infection from breeding herds [?], [?], [?], [?].
| HUNGARY |
Stipkovits, L. and others (2004) |
| MICs (µg/ml) of ten isolates of M. hyopneumoniae to various antimicrobials |
| Antimicrobial |
MIC range
|
MIC50
|
MIC90
|
| Doxycycline |
0.5 - 32.0
|
4.0
|
16.0
|
| Chlortetracycline |
4.0 - 32.0
|
16.0
|
32.0
|
| Tylosin |
0.25 - 16.0
|
2.0
|
16.0
|
| Tilmicosin |
0.125 - 2.0
|
0.25
|
2.0
|
| Lincomycin |
0.25 - 8.0
|
2.0
|
8.0
|
| Tiamutin® (tiamulin) |
0.06 - 1.0
|
0.25
|
1.0
|
|
| 
