Denagard® 45% Water Soluble Powder (Typical)

500g pack
 

Tiamulin hydrogen fumarate (thf)
For oral administration in the drinking water of pigs.

A white granular powder containing 450mg tiamulin hydrogen fumarate per g.

The following organisms show sensitivity to tiamulin hydrogen fumarate in vitro:
Brachyspira: Brachyspira hyodysenteriae, B. pilosicoli.
Mycoplasmas: Mycoplasma hyopneumoniae, M. hyorhinis,
M. hyosynoviae, Ureaplasma spp, M. gallisepticum, M. synoviae,
M. meleagridis.
Gram-positive: Staphylococcus spp., Streptococcus spp., Arcanobacterium pyogenes.
Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus spp., Haemophilus spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli, Lawsonia intracellularis.

Denagard 45% Water Soluble Powder is indicated for use in the treatment and prevention of bacterial and mycoplasmal infections caused by tiamulin sensitive organisms involving the intestinal and respiratory tracts and joints.

Denagard 45% Water Soluble Powder should be administered in the drinking water for:
 

Pigs:
Swine dysentery treatment:
1g/7.5 L (0.006% thf, 60 mg thf /litre) for 3-5 consecutive days, depending on the severity of the infection and/or the duration of the disease. The target dosage is 8.8 mg thf/kg bodyweight per day. The contents of each pack will treat 340 pigs of 25 kg bodyweight for 3 days or 204 pigs of 25 kg bodyweight for 5 days.
 

Enzootic Pneumonia treatment:
1g/3.6 L (0.0125% thf, 125 mg thf/litre) for 3-5 consecutive days. The target dosage is 18.3 mg thf/kg bodyweight per day. The contents of each pack will treat 163 pigs of 25kg bodyweight for 3 days and 98 pigs of 25kg bodyweight for 5 days.
 

To ensure the desired intake Denagard 45% Water Soluble Powder may be administered in one of two ways:

• In approximately one half of the daily water requirements to ensure consumption of the correct dose. Unmedicated water should be provided each day after the medicated water has been consumed.
• Administered continuously at the required level in the drinking water as the only source of drinking water.
  Where a water medicator is used the appropriate stock solution should be made up according to the maker’s instructions.

Warnings:
Animals must not be slaughtered for human consumption during treatment.
 

Pigs may be slaughtered for human consumption only after 2 days from the last treatment.
 

Contra-indications:
Do not use in animals hypersensitive to the active ingredient. Animals should not receive feed containing monensin, narasin or salinomycin, during or for at least seven days before or after treatment with Denagard. Severe growth depression or death may result.
 

In order to avoid interactions between tiamulin and the incompatible ionophores monensin, narasin and salinomycin, the feed mill supplying the feed should be notified that tiamulin will be used and that these products should not be included in the feed or contaminate the feed. The feed should be tested for the ionophores prior to use if there is any suspicion that contamination of the feed might occur. If an interaction does occur, stop tiamulin water medication immediately and replace with fresh water. Remove contaminated feed as soon as possible and replace with feed not containing the tiamulin-incompatible ionophores.
 

Operator Warnings:
When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses.
 

In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists.
 

Contaminated clothing should be removed and any splashes on to the skin should be washed off immediately.
 

Pregnancy and Lactation:
Denagard 45% Water Soluble Powder is suitable for use during pregnancy and lactation.
 

Pharmaceutical Warnings:
Fresh medicated water must be prepared every 24 hours. Watering equipment should be thoroughly cleaned prior to addition of Denagard 45% Water Soluble Powder. Do not store above 25°C. Protect from light.
 

Precautions:

• For use in drinking water of pigs.
• Monitor water intake at frequent intervals during medication.
• If there is no response to treatment within five days, the diagnosis should be re-established.
• On rare occasions erythema or mild oedema of the skin may occur in pigs following the use of tiamulin hydrogen fumarate.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
 

For animal treatment only.
 

Keep out of reach of Children.
 

® Registered trademark of Novartis AG, Basel, Switzerland.