Tiamutin pharmacodynamics

Evaluation of the effects of antibiotics, at sub-MIC levels, on bacteria can provide useful information pertinent to rational clinical use.
 

It has been reported [?] that tiamulin, at sub-MIC levels, (MIC/2, MIC/4, and MIC/8) markedly reduced the growth of Pasteurella multocida (PM) and App, greatly affected the morphology of PM and App and inhibited their capsule production. Haemolysin production was also curtailed. Thus, even at low concentrations Tiamutin can reduce the pathogenicity of App and PM.

The usefulness of antibiotics in the treatment of infections caused by facultative intracellular pathogens, e.g. Lawsonia intracellularis, depends on their ability to enter, accumulate and persist in cells and to inhibit the ingested organism.
 

Tiamutin has been shown to penetrate into cells (e.g. human polymorphonuclear leucocytes) and produce intracellular concentrations several times higher than the extracellular concentration [?].