Ileitis - trial data

The chronic and subclinical forms of PPE are known as ileitis. On a typical pig unit affected with ileitis observations of chronic and subclinical cases reveal:

• diarrhoea and reduced weight gains

• or ‘variation’ in the weights of groups of growing pigs 7-20 weeks old.
   

Diarrhoea and poor weight gains are often seen together in a group of pigs but not necessarily in the same pigs. [?]
 

Tiamutin® premix and Tiamutin® water soluble powder have been demonstrated in a number of published studies to provide dramatic improvements in average daily gain and feed conversion efficiency in growing pigs affected by ileitis. [?] Schwartz and others (1999) described the successful prevention/control of ileitis using Tiamutin® Premix (38.5 ppm tiamulin hydrogen fumarate for 35 consecutive days – 7 days pre-infection and 28 days post-infection). The reported improvements in productivity were as follows:

 

	Schwartz and others (1999)
Tiamutin® (tiamulin) productivity improvements
Infected non-medicated group Infected Tiamutin medicated (38.5 ppm thf) group Index Average daily gain (g) 499 640 128.3% Feed conversion efficiency (days 0 - 35) 2.13 1.96 92% (8% imp.)

Thus over a 28 day period Tiamutin® premix medication improved average daily gains by 28.3% and feed conversion efficiency of 8% compared to un-medicated infected control pigs.

Walter, D. and others (2001) [?] described the successful treatment of an artificially induced ileitis infection with Tiamutin® Premix (38.5 ppm thf for 28 consecutive days). The productivity improvements recorded were comparable with those of Schwartz and others (1999) [?] described earlier.

 

	Walter, D. and others (2001)
Tiamutin® (tiamulin) productivity improvements
Infected non-medicated group Infected Tiamutin medicated (38.5 ppm thf) group Index Average daily gain (g) 409 528 129.1% Feed conversion efficiency 1.852 1.585 85.6% (14.4% imp.)

 
 

Figure below summarizing the results on gross lesions, microscopic lesions and reduction in Li shedding.
 

 
 

Tiamutin® (tiamulin) - Ileitis Control via feed application

 

A third study, Tsinas, A.C. and others (1998), [?] described the successful use of Tiamutin® Premix on a farm with a history of PPE outbreaks. 2 groups of 48 pigs received either no medication or medication as follows:

Negative controls	-	infected, non medicated
Tiamutin® medication	-	water and feed -60 mg thf in water for 3 consecutive days + thf in feed 35 ppm continuously for approximately 20 weeks.

	Tsinas, A.C and others (1998)
Tiamutin® (tiamulin) productivity improvements
Infected non-medicated group Infected Tiamutin medicated group Index Average daily gain, g (days 21 - 161) 571.92 725.42 126% Feed conversion efficiency (days 21 - 161) 2.94 2.53 86.1% (13.9% imp.)

Thus, as in the previous two studies, Tiamutin medication produced major improvements in both average daily gain and feed conversion efficiency in pigs affected with ileitis.
 

Tiamutin® can be used with confidence for the effective treatment and control of ileitis and can also provide substantial improvements in the productivity of affected pigs affected with ileitis.

In a challenge study (2000) conducted by Walter, D. and others Tiamutin® water soluble powder controls effectively the clinical, pathological and negative productivity effects of ileitis in growers. Tiamutin® water soluble powder was used in a dose level of 60ppm for 5 consecutive days.
 

 
 

Tiamutin® (tiamulin) - PPE Treatment via drinking water
Unmedicated infected controls Tiamulin P-value Index Daily gain (g) 510 641   0.007 25.7%   Feed conversion 1.89 1.58 0.010 16.4% imp.

 
 

Figure below summarizing the results on gross lesions, microscopic lesions and reduction in LI shedding.
 

 
 

Tiamutin® (tiamulin) - PPE Treatment via drinking water

 

Tiamutin® water soluble powder was highly effective in minimizing the negative impact of ileitis on the performance of pigs in a study conducted in the United States. Tiamutin® water soluble powder was used at a dose level of 60ppm thf for 5 consecutive days.

 
 

Tiamutin® (tiamulin) - PPE Treatment via drinking water

Non medicated Non infected 0 ppm (n=9) Tiamutin 60 ppm thf (n=9) Non medicated Infected 0 ppm (n=9) P-value  Li challenge No Yes Yes   Mean bodyweight (kg) Day 0 (challenge) 10.84 10.61 10.84 - Day 7 (administer trt) 13.94 a 12.39 b 12.48 b < 0.01 Dat 12 (remove trt) 16.96 a 14.28 b 13.69 b < 0.001 Day 22 (necropsy) 22.86 a 18.42 b 15.16 c < 0.05 Performance parameters days 7 - 22 ADG, g (+SD) 594 a (+154) 402 b (+195) 179 c (+185) < 0.05 ADFI, g (+SD) 1146 a (+149) 908 b (+179) 855 b (+172) < 0.05 ADG:ADFI 0.518 a 0.424 a 0.201 b < 0.05 ADWI, g (+SD) 3116 a (+805) 2457 b (+764) 2592 b (+1033) - Mortality 0/9 0/9 0/9   ADG = average daily weight gain    ADFI = average daily feed intake    ADWI = average daily water intake  abc – means with the same letter are not different