Tiamulin has been shown to be highly active in vitro against Lawsonia intracellularis (L.i.) by both intracellular and extracellular activity assays. [?] It is particularly suitable for the effective control of L.i. infections as it concentrates inside the cells where the organism lives. (See table below)
| UK |
McOrist, S. (1995) |
| MICs µg/ml of varioius antibiotics for L. intracellularis |
| |
|
MIC (µg/ml) |
| Antimicrobial |
No of strains tested |
Intracellular
activity assay |
Extracellular
activity assay |
| Tylosin tartrate |
3 |
64 |
64 |
| Lincomycin HCL |
2 |
32 |
32 |
| Spectinomycin |
1 |
32 |
32 |
| Tiamutin® (tiamulin) |
3 |
4 |
4 |
|
Tiamulin has been shown in vivo to be effective against ileitis, which does not respond clinically to tylosin [?] and has been used in successful attempts to eradicate L.i. infection. [?]
| 
