Ileitis (PPE) is a common enteric disease of post-weaned pigs in pig producing countries world-wide. In the USA it has replaced swine dysentery as the most important bacterial enteric disease of pigs and 96.2% of US pig herds are now infected with it. [?]
Tiamulin, which acts intracellularly [?], is highly active against L.i. [?] and inhibits L.i. at its site of infection.
Ileitis and Colitis (PCS) are known to occur concomitantly with the post-weaning multi-systemic wasting syndrome (PMWS) associated with PCV-2 virus infection.
Porcine proliferative enteropathies (PPE) are caused by an obligate, intracellular Gram-negative bacterium, Lawsonia intracellularis and are becoming increasingly well recognized world-wide as a cause of serious economic losses.
PPE presents clinically in both acute (PHE, Proliferative Haemorrhagic Enteropathy) and chronic forms (PIA, Porcine Intestinal Adenomatosis, Ileitis). It also occurs as a sub-clinical condition with apparent wasting of well grown young pigs. PPE can occur either alone or as a mixed infection, commonly with Brachyspira pilosicoli (B.p), the cause of PCS.
Serological tests and PCR testing have identified two patterns of infection. The chronic and sub-clinical forms of the disease are especially common in growers on traditional single site, continuous flow, farrow to finish farms. The acute form of the disease in finishers and breeders, conversely, occurs on multiple site, ‘all-in all-out’ farms with separation of sows and young piglets.
Denagard is particularly suitable for delivering effective control of L.i. infection as it concentrates inside the cells where the organism lives. It is 16x more potent in vitro than tylosin against L.i. [?] and is active in vivo against strains of L.i. which are clinically non-responsive to tylosin. [?]
The acute form of the disease, which is often life threatening can be treated with Denagard injectable or water soluble, whilst the chronic form can be controlled with premix.
The mixed infections of L.i. + B.p. [?] and L.i. + B. hyo can be reliably controlled with Denagard premix since all these organisms are highly susceptible to Denagard.
